Re: Which mass spectrometer system is best for proteomics?
Lance,
This sort of question has been batted around many times, particularly on the ABRF discussion group (http://www.abrf.org). If you are looking for a proteomics "solution", there are probably a number of arguments for or against MALDI, depending on the work that you want to do. You can see from the survey of this site that ESI-ion trap is the most popular instrument, but that's probably because most of our content is focused on LC/MS. It appears that most labs are using MALDI mass matching for high-throughput protein i.d., but they are using LC/MS/MS (either ion trap, QTOF, or both) as a backup when the MALDI data are ambiguous. Other labs with more difficult samples are using almost all LC/MS/MS. The goals and applications that you have in mind will ultimately determine what instrument would be the best purchase. It would be hard to give any detailed advice base on your short question.
I would have a look at the ABRF discussion group archives. Here's a link to the main search page.
http://www.abrf.org/index.cfm/list.home
Here's an interesting bit of advice that turned up in a search that I did:
http://www.abrf.org/archives/hmail/9828/0039.html
Also, we (Novatia) could also work with you in a consulting mode to determine which instrument would best fit your application requirements.
Regards,
Mark Hail
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