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Metabolism Screening Assays

Author:   Jeff Whitney  
Posted: 12/20/04; 3:24:28 PM
Topic: Metabolism Screening Assays
Msg #: 361 (top msg in thread)
Prev/Next: 360/362
Reads: 13091

Novatia offers high-throughput in-vitro data of drug metabolic stability, half-life determination, and P450 enzyme specificity studies.  We provide non-cellular and cellular assays that utilize a rapid highly specific LC/MS/MS detection.  Custom reports are generated which allow for rapid data evaluation.  Chemists in your organization can then intelligently and quickly incorporate the information into the next synthetic series of compounds.

 

   Assay options offered:

  • Non-cellular conditions using microsomes, S9, cytosol extracts, etc. from multiple species
  • Cellular conditions using fresh, cryo-preserved, and immortal hepatocytes, etc. from multiple species and cell lines
  • Wide range of compound concentrations allowed
  • Customized assay development and reporting

Again, all analyses are performed using high-throughput LC/MS/MS methods for speed, sensitivity, and specificity.  We also encourage assay customization which offers the best chance of integrating our results into your process.  We have automated data processing routines in place to provide further ease of data reporting.  Reporting can also be customized to meet your needs.

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Help link
 7/24/08; 9:29:59 PM.

 

Half-Life Determination Example:

MET_screens_1: Metabolism Screening Assays Figure 1

Tabular Half-Life results for six compounds in Human Liver Microsomes

Download the metabolism analysis services brochure.

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