A New Gear for NMR
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The process of pharmaceutical research and development (R&D) has changed significantly over the last ten years characterized perhaps most notably by the introduction of high throughput methods to many areas. This trend, driven by new technologies such as combinatorial chemistry and genomics, is challenging the traditional application of Nuclear Magnetic Resonance (NMR): a detail oriented technique that is time consuming, expertise intensive and therefore not suitable for high throughput studies. These factors manifest as an increase in diversity, complexity and number of samples that when coupled with business trends to shorten discovery and development cycle times present an imperative for new method development in NMR. A "New Gear" for NMR is needed that can place the technique in more front-line studies providing information consistent with the compressed timelines. The success of this effort has three fundamental requirements: the definition of experimental methods that provide information quickly; the availability of low-cost NMR instrumentation; and the adoption of these methods and instrumentation into the vernacular of biological and chemical research. We have been working to address the first requirement by developing NMR Profile Methods that can provide information more rapidly through a strategy of sacrificing detail to save time.
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Top 5 hits for High Throughput Pharmaceutical NMR on..
 | 7/24/08; 9:53:07 PM. |
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We have described some of our efforts to develop and apply high throughput NMR methods. It seems that NMR is at the beginning of a period of expansion, rediscovery and new utility in biological and chemical research. However in some sense, there is a bootstrap problem in that low-cost instrumentation needs to be available and more profile methods defined for this expansion to occur. Recent developments in instrumentation including pulse field gradients (allow for diffusion NMR and more rapid acquisition of datasets), flow NMR probes (facilitate faster sample preparation and delivery) and actively shielded magnets (reduce instrument space requirements) are enabling new NMR applications. However, more can be done in terms of lowering cost and reducing size by identifying minimal instrumental requirements to support key NMR profile applications. Or more succinctly, what are the killer NMR applications and what are the core instrument capabilities required to support them? This is a riddle worth solving as the results presented here suggest that NMR can be made responsive to the emerging needs of high throughput analysis. This "New Gear", along with the traditional detailed NMR studies bracket a continuum (less detailed and fast to more detailed and slow) that position NMR for increased flexibility allowing it to continue to play a critical role in Pharmaceutical R&D.
 
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