| Your need for rapid assay turnaround time is important, but one must also pay particular attention to scientific integrity. It is equally important that you can trust the assay results from your metabolic screens. Frequently drug candidates have purity, solubility and chemical stability issues that go undetected. These can generate misleading results while screening that are difficult to troubleshoot post-assay. We at Novatia advocate starting with the Pre-assay Integrity Screening to characterize your compounds in the context of the assay. This is to insure quality results from your submitted samples. The Pre-assay Integrity Screen determines the ìdrug candidateísî purity, stability, solubility and MS performance from two samples using LC/UV/MS: one sample dissolved in 100% organic and the other in assay buffer. |