Oligo HTCS Systems

Introducing the first fully-automated systems for oligonucleotide LC/MS!

The Oligo HTCS family of instruments are the only LC/MS systems designed to automate every aspect of oligonucleotide mass spectral analysis. The HTCS takes care of sample injection, desalting, detection, as well as data processing and reporting. With a sample throughput of up to 3000 samples/24 hrs, no LC/MS system on the planet is as productive as the Oligo HTCS. The HTCS allows you to characterize long (>120mers) or fragile oligos that are not amenable to MALDI-ToF. In fact, the HTCS is the only fully-automated MS system which can effectively QC oligos to be used in longmer DNA microarrays. Just as easily, the HTCS can also perform detailed LC/UV/MS profiling on your high-value oligos to give you full information about impurities, degradants, and failure products. Our ProMass software ties it all together, allowing you to process and communicate your results effortlessly. oligohtcslogo

Download the Oligo HTCS brochure (PDF)

Applications include:

120-mer oligo spectrum 96-well plate view and mass spectrum of a 120-mer oligo acquired with the Oligo HTCS system
Mass = 37031 Da, Mass Error = 0.6 Da

System Highlights

A choice of system configurations is available. Simply choose an appropriate system that is matched to your throughput, applications, and budget requirements.

Features & Benefits

All of our Oligo HTCS systems offer the following:

Choice of Two Different HT Platforms!

Oligo HTCS UltiMate System Oligo HTCS UltiMate system, featuring: the LTQ-XL mass spectrometer, UltiMate 3000 HPLC, and HTC-PAL-xt autosampler
Oligo HTCS Twin UltiMate System Oligo HTCS Twin UltiMate system, featuring: the LTQ-XL mass spectrometer, UltiMate 3000 HPLC, and Twin HTS-PAL-xt autosampler

What’s Included with the Oligo HTCS System

The Oligo HTCS includes everything you need to characterize your oligos using either high-throughput or detailed LC/MS methods. We install the system, provide detailed training for your users, and guarantee your success with the application. As part of the package, we provide ready-to-run methods for both high-throughput analysis and detailed LC/UV/MS profiling of oligos. Our standard Oligo HTCS package includes:

Who uses the Oligo HTCS systems?
Oligo HTCS systems are in use world wide in DNA/RNA manufacturing and pharmaceutical research environments. Some of our users include:

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