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Protein MS

Protein LC/MS Analysis Services

Features and Benefits of Novatia Protein LC/MS ServicesApplications

  • Excellent mass accuracy, typically ± 0.01% (i.e., 1 Da in 10 kDa)

  • Mass resolution better than MALDI, particularly for large proteins (>20 kDa)

  • Applicable to large proteins, including intact antibodies

  • Methods for detailed profiling and/or high-throughput MW determination are available.

  • Chromatographic separation often reveals components not seen by MALDI or direct injection ESI.

  • Unparalleled ProMass ESI spectral deconvolution technology

  • Our system can analyze proteins in high concentrations of salts, buffers, or other contaminants.

  • Backed by over 25 years experience in biological mass spectrometry

  • We also specialize in oligonucleotide characterization.

  • Confirm MWs of target proteins

  • Monitor production of biomolecule therapeutic products

  • Validate sample integrity before using proteins in costly high-throughput screening or structural biology studies

  • Screen for possible post-translational modifications

  • Measure the number of covalent modifications in antibody-drug conjugates

  • Assess sample heterogeneity or effectiveness of purification methods

  • Compare proteins from different production lots for consistency

  • Bioprocess impurity profiling and troubleshooting