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Oligonucleotide LC/MS Analysis Services

Characterization Of Oligonucleotides

Why should you consider Novatia and ESI/LC/MS for your oligonucleotide characterization? Novatia uses electrospray ionization liquid chromatography mass spectrometry (ESI/LC/MS) to characterize oligonucleotides. We can perform these analyses in a high-throughput mode to confirm the desired products from oligo synthesis reactions or in a more detailed mode using high resolution chromatographic separation. Most laboratories uses MALDI-ToF and/or gel electrophoresis to characterize oligos. Novatia has developed the Oligo HTCS automated LC/MS system, which provides a number of advantages relative to MALDI-ToF and other traditional methods for oligo characterization.

Features and Benefits of Novatia Oligo LC/MS Analysis Services:

Oligonucleotide Sequence Confirmation

Novatia uses a unique approach that utilizes high resolution hybrid LTQ-Orbitrap mass spectrometry and novel deisotoping and charge deconvolution software for MS-based oligonucleotide sequencing.  The approach allows us to confirm oligonucleotide sequences from their MS/MS fragmentation patterns.

Contact us for more information about sample requirements and pricing.