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Protein LC/MS Analysis Services

Features and Benefits of Novatia Protein LC/MS Services	Applications
Excellent mass accuracy, typically ± 0.01% (i.e., 1 Da in 10 kDa) Mass resolution better than MALDI, particularly for large proteins (>20 kDa) Applicable to large proteins, even intact antibodies Methods for detailed profiling and/or high-throughput MW determination are available. Chromatographic separation often reveals components not seen by MALDI or direct injection ESI. Unparalleled ProMass ESI spectral deconvolution technology Our system can analyze proteins in high concentrations of salts, buffers, or other contaminants. Backed by over 15 years experience in biological mass spectrometry We also specialize in oligonucleotide characterization.	Confirm MWs of target proteins Monitor production of biomolecule therapeutic products Validate sample integrity before using proteins in costly high-throughput screening or structural biology studies Screen for possible post-translational or other covalent protein modifications Assess sample heterogeneity or effectiveness of purification methods Compare proteins from different production lots for consistency Bioprocess impurity profiling and troubleshooting

Features and Benefits of Novatia Protein LC/MS Services

Applications

Excellent mass accuracy, typically ± 0.01% (i.e., 1 Da in 10 kDa)
Mass resolution better than MALDI, particularly for large proteins (>20 kDa)
Applicable to large proteins, even intact antibodies
Methods for detailed profiling and/or high-throughput MW determination are available.
Chromatographic separation often reveals components not seen by MALDI or direct injection ESI.
Unparalleled ProMass ESI spectral deconvolution technology
Our system can analyze proteins in high concentrations of salts, buffers, or other contaminants.
Backed by over 15 years experience in biological mass spectrometry
We also specialize in oligonucleotide characterization.

Confirm MWs of target proteins
Monitor production of biomolecule therapeutic products
Validate sample integrity before using proteins in costly high-throughput screening or structural biology studies
Screen for possible post-translational or other covalent protein modifications
Assess sample heterogeneity or effectiveness of purification methods
Compare proteins from different production lots for consistency
Bioprocess impurity profiling and troubleshooting

Novatia