Features and Benefits of Novatia Protein LC/MS Services:

• Excellent mass accuracy, typically ± 0.01% (i.e., 1 Da in 10 kDa)
• Mass resolution better than MALDI, particularly for large proteins (>20 kDa)
• Applicable to large proteins, even intact antibodies
• Methods for detailed profiling and/or high-throughput MW determination are available.
• Chromatographic separation often reveals components not seen by MALDI or direct injection ESI. 
• Unparalleled ProMass ESI spectral deconvolution technology
• Our system can analyze proteins in high concentrations of salts, buffers, or other contaminants.
• Backed by over 15 years experience in biological mass spectrometry
• We also specialize in oligonucleotide characterization.

Applications:

• Confirm MWs of target proteins
• Monitor production of biomolecule therapeutic products  
• Validate sample integrity before using proteins in costly high-throughput screening or structural biology studies
• Screen for possible post-translational or other covalent protein modifications
• Assess sample heterogeneity or effectiveness of purification methods
• Compare proteins from different production lots for consistency
• Bioprocess impurity profiling and troubleshooting