Novatia : High Sensitivity Capillary NMR Analysis

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High Sensitivity Capillary NMR Analysis

Novatia is the only contract NMR laboratory that offers high sensitivity (microgram to nanaogram scale) NMR contract analysis specifically designed for:

natural product and other isolation chemists
synthetic chemists (especially where synthesis is multistep and low yield)
chemists & biologists with limited sample supply
If you are familiar with the sensitivity limits of NMR, you'll recognize the results below are on impressively small amounts of material to consider for routine NMR work. The figures below example results obtained at 500 MHz. More examples of Novatia's trace NMR analysis using CapNMR are also available. Novatia offers two routes to our NMR services: data-only where we collect the data and you do the spectral interpretation or data plus where we provide partial or full interpretation. Pricing and Sample Submission information available, or Contact us today to discuss your needs.

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1D ¹H NMR Spectra on nanograms

For example, our system enables routine ¹H proton data to be collected on as little as 500 ng in less than 1 hour. The figure on the right shows the spectrum of 200 ng (1.5 nMoles) of hisidiine collected in 50 minutes on a 500 MHz instrument. Histidine resonances are visible at 7.5, 7, 4.8 and a pair at 3 ppm. Data were collected in 90:10 D20:dAcN. Additional resonances are due to protonated solvents and impurities.

NMR_histidine_1D: 1D proton spectrum of 200 ng of histidine at 500 MHz in 50 minutes with CapNMR.

2D ¹H-¹³C Correlation Spectra on micrograms

¹H-¹³C 2D correlation experiments (e.g., HSQC, HMBC) provide critical structure elucidation and conformation data allowing for completed and unambiguous structure determination of compounds. Novatia's High Sensitivity NMR package also includes the ability to get these important data sets on as little as a few micrograms of material. The figure on the right on shows the ¹H-¹³C HMQC data obtained on 15 ug (50 nMoles) of sucrose in 14 hours at 500 MHz.

NMR_sucrose_hmqc: HMQC of 50 nMoles (15 ug) of Sucrose in 14 hours at 500 MHz with CapNMR.

More examples of Novatia's trace NMR analysis using CapNMR