Expertise

LC/MS and LC/MS/MS applications for pharmaceutical research

• Intact molecular weight analysis of biomolecules
• Heterogeneity profiling
• Post-translational modifications
• Proteomics analysis including protein identification and sequencing
• Broad expertise analyzing oligonucleotides, proteins (e.g. mAbs), antibody-drug conjugates, small molecules and macrolides (e.g. tacrolimus derivatives, ascomycin, rapamycin, everolimus, and cyclosporin)

Pharma Support Services

• Impurity / Degradant isolation and structure elucidation for small molecules and biomolecules
• HPLC Relative Response factor determination using qNMR
• Chemical Kinetics Studies
• Fate of Impurity Investigations
• Competitor Product Analyses
• API Manufacturing Troubleshooting
• CMC support services

Instrumentation

• High field NMR with cryoprobe
• High resolution accurate mass MS and LCMS
• Ion trap (nominal) mass spectrometry
• Electrospray ionization (ESI) and atmospheric chemical ionization (APCI)
• HPLC, UPLC
• GCMS

NMR applications for pharmaceutical research

• Structure elucidation
• cGMP testing and product release
• Polymer NMR

For more information on real-world examples of our expertise, check out our Products page, or if you want more information on our background you can read our People page.