Expertise
LC/MS and LC/MS/MS applications for pharmaceutical research
- Intact molecular weight analysis of biomolecules
- Heterogeneity profiling
- Post-translational modifications
- Proteomics analysis including protein identification and sequencing
- Broad expertise analyzing oligonucleotides, proteins (e.g. mAbs), antibody-drug conjugates, small molecules and macrolides (e.g. tacrolimus derivatives, ascomycin, rapamycin, everolimus, and cyclosporin)
Pharma Support Services
- Impurity / Degradant isolation and structure elucidation for small molecules and biomolecules
- HPLC Relative Response factor determination using qNMR
- Chemical Kinetics Studies
- Fate of Impurity Investigations
- Competitor Product Analyses
- API Manufacturing Troubleshooting
- CMC support services
Instrumentation
- High field NMR with cryoprobe
- High resolution accurate mass MS and LCMS
- Ion trap (nominal) mass spectrometry
- Electrospray ionization (ESI) and atmospheric chemical ionization (APCI)
- HPLC, UPLC
- GCMS
NMR applications for pharmaceutical research
For more information on real-world examples of our expertise, check out our Products page, or if you want more information on our background you can read our People page.