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MS Sample Submission Guidelines

MS Sample Requirements

  • Minimum sample amounts
    • Oligonucleotides
      • Submit > 1 nmol if sending an oligonucleotide for oligo sequencing
      • Submit > 50 pico moles for oligo analyses. An ideal oligo submission for routine work would be at least 30 microliters of 5 micromolar sample
    • Proteins/ Peptides
      • 50-100 ug (e.g. 2 mg/ mL x 25-50 uL) for peptide mapping
      • 20-40 ug (e.g. 2 mg/mL x 10-20 uL) for Native MS methods
      • 10-20 ug (e.g. 1 mg/mL x 10-20 uL) for all other protein/peptide analysis.
  • Samples can be dry or lyophilized sample (specify grams or moles) or in solution (specify volume & concentration)
  • If the samples contain any detergent (Tween, TritonX, etc) tell us in the comments and provide an estimated concentration.
  • Provide target molecular weight, molecular formula, or structure.
    • Oligonucleotide sequences (use IDT designation as specified at IDT Oligo Nomenclature) this includes sequence modifications if they are available. If the modification is unique please provide a molecular formula or structure.
  • If submitting a small molecule, please indicate the structure and/or functional groups, a solvent, and any other important information in the Comments field of the Excel sheet

When submitting a plate:

    • To qualify for plate pricing:
    • To prevent cross-contamination and potential sample loss, it is best to ship them either on dry ice, or dried-down.
      • Even the best plate seals it is likely that cross-contamination will happen during the shipping process.
    • Specify the plate position for each sample in the excel sheet.

MS Analysis Time

  • Our turnaround time is 1-5 business days starting when the sample has been received at Novatia.
  • We take pride in our fast turnaround time of sample analysis, for oligonucleotide MW Confirmation usually within 1 business day of sample receipt and routine purity profile samples usually within 2 business days of sample receipt

MS Results:

  • Web-based ProMass report available at our secure data server for biomolecules
  • ACD reports for small molecules

Please be sure to download our most recent blank routine sample submission sheet

Still have additional questions? Contact us for additional support