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MS Oligonucleotide Pricing

Standard pricing for oligonucleotide mass spectral analysis

About Novatia’s oligonucleotide analysis
How Do I Get My MS Results and What Will They Look Like?

All analyses use electrospray ionization (ESI)

Not sure if you need High Resolution or not? Click here

Looking for analysis of short oligonucleotides <3 bases? Check out our small molecule methods.

For questions about our MS analysis, email ms@enovatia.com.

 

Standard Nucleotide Analysis

AnalysisPrice Per Analysis96-well Plate Pricing384-well Plate PricingDescriptionExcel Sample Submission Sheet Code
Flow Injection / Molecular Weight Confirmation$100$1200 full plate

Partial plate pricing:
Plate set up fee of $480 + $7.5 per sample in the plate.
There is a minimum charge of $630 for partial plates.
$2400 per plate

Bulk discount: $1920 per plate (5 or more plates in a single submission)*
Lowest-cost option for MW confirmation, nominal massMW_Confirmation
5 Minute LC/MS Gradient$150$3000 full plate

Partial plate pricing:
Plate set up fee of $480 + $26.25 per sample in the plate.
There is a minimum charge of $1005 for partial plates.
N/ALower-cost option for impurity profilingLCMS_5_min
20 Minute LC/MS Gradient$250N/AN/ABetter for more detailed oligonucleotide and long oligo (>80 bases) impurity profiling applicationsLCMS_20_min
Analyses available for both DNA and RNA. Please provide oligonucleotide sequences using IDT format.

*Large quantities of samples may take longer.

High Resolution/Accurate Mass (HRMS) Nucleotide Analysis

AnalysisPrice Per AnalysisDescriptionExcel Sample Submission Sheet Code
Flow Injection / Exact Mass Determination$150Desalting ESIHRMS
LC/MS$350The best and most accurate method for impurity profiling (<80 bases). Can be used for unmodified or modified oligos (including PEGylated oligos). HRMS_LCMS
LC/MS Analysis of mRNA samples$350Analysis of capped mRNA species (10-30 nt long) or Poly A tails (~120 nt long)

Visit our mRNA analysis page to view more details:
HRMS_LCMS or HRMS_LCMS_PolyAtail
Sold phase extraction and HRMS_LCMS analysisSet up fee of $500 + $450 per sampleSPE clean up of oligonucleotide (<80 bases) samples that contain excess protein content or in biological matrices. Followed by HRMS_LCMS analysisSPE_HRMS_LCMS
Oligonucleotide Sequencing$1000MS/MS oligo sequence confirmation for oligos up to 40 bases in length, includes exact mass determination. Includes Microsoft Excel report. Pricing is per oligo strand.

Best for confident submitters able to interpret results without assistance.
Oligo_Sequencing
Oligonucleotide Sequencing with a Full Report$3000MS/MS oligo sequence confirmation for oligos up to 40 bases in length, includes exact mass determination. Includes a detailed custom report. Pricing is per oligo strand.

Best for submitters requiring detailed reports and interpretation.
Oligo_Sequencing_Full_Report
Oligo metabolite identification :  including incubation in bio matrices (serum, plasma, etc.), sample extraction,  and high-resolution accurate mass analysis to determine metabolites and the rate of disappearance of the parent compound: inquire.    

Nucleotide Analysis Samplers

Best for new customers who want to compare our different analysis options for Nucleotides.
AnalysisPrice Per AnalysisDescriptionExcel Sample Submission Sheet Code
Standard versus High Resolution $250Compare our standard MS analysis to High resolution data on the same sample. Results will be provided in a single ProMass report.
Two analysis will be performed:
Our standard MW_confirmation and HRMS flow inject methods.
It is recommended to submit a minimum of 100 pico moles sample in one tube for the best results.
Flow_inject_sampler
5-Minute LCMS versus 20-Minute LCMS$400Compare our standard nucleotide LCMS analysis options on the same sample. Results will be provided in a single ProMass report.
Two analysis will be performed:
Our standard LCMS_5_min and LCMS_20_min methods.
It is recommended to submit a minimum of 100 pico moles sample in one tube for the best results.
LCMS_sampler
Nucleotide MS Analysis Sampler$1000Compare a number of our standard and high resolution analysis options on the same sample. Results will be provided in a single ProMass report.
Five analysis will be performed:
Our standard MW_confirmation, LCMS_5_min, and LCMS_20_min methods. As well as our high resolution HRMS and HRMS_LCMS methods.
It is recommended to submit a minimum of 250 pico moles sample in one tube for the best results.
Complete_oligo_sampler

Additional Services

ServicePrice
Applicable to:
Additional Data Interpretation & Reporting$400 / hrMS and NMR analysis
Sample Return$300 MS and NMR analysis
Variable Temperature$350 setup feeNMR Analysis only
Extended NMR Acquisition (1, 2, 4, 8 hours)$200/ hourNMR Analysis only
50-minute training session (see details below)$400MS and NMR analysis
50-minute training session: This service is meant to highlight the data provided in the report and how to view the posted MS or NMR data. This service is not meant to troubleshoot potential sample issues. Beneficial for first time submitters as we will explain the information provided in the data we have posted. If requesting this service, the results notification email sent by the analyst will provide times available to review the posted results. You will need to schedule a time that works best within the next 5 business days from the day the results email is sent.

Pricing and policies effective 09-Sept-2023.

ROUTINE ANALYSIS TERMS AND CONDITIONS:

  1. Typical turnaround time is 1-5 business days for most analyses. Rush service moves your submission to the front of the instrument queue for 2X charge. Peptide mapping usually within one week. Nominal mass oligonucleotides and 1D NMR usually same day or next day. Large numbers of samples may take longer.
  2. Payment for services will be made by check, credit card, wire transfer or ACH.  An approved purchase order (Net 30) or credit card details will be provided to Novatia upon submitting an analysis request: http://www.enovatia.com/novatia-sample-submission-form/ When paying by credit card, transactions will process at the time service is provided. Invoices are due and payable within the time noted on the invoice, measured from the date of the invoice.
  3. Work is NOT performed under regulated conditions (e.g. cGxP) and is “for information only.”
  4. Customer represents that submitted samples do not warrant exceptional handling or precautions (e.g., as with radioactive samples, controlled substances, highly potent or cytotoxic compounds, etc.) and that any available safety information (safety data sheet, occupational exposure level, control banding, etc.) will be relayed to Novatia prior to sample shipment.
  5. After analysis, customer will receive an email to view results on Novatia’s Secure Web Portal: Most MS results are ProMass HTML or ACD PDF report;  NMR results include ACD PDF report and zip file of raw NMR data.
  6. If additional custom data interpretation/reporting is required (apart from what is explicitly included in Point 5), Novatia can provide a quote to the customer at our hourly rate of $400/hr.