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PEGylated Oligonucleotide Analysis

Novatia offers LC/MS analysis of PEGylated oligonucleotides on our high resolution mass spectrometers (orbitrap or QTof) using our ProMass Deconvolution technology. This analysis can reveal:

1. The molecular weight distribution of a PEGylated oligo;

2. How much free oligo is present in a sample; and

3. What the lot-to-lot consistency (or variability) is among multiple samples.

ESI mass spectrum (raw data): Deconvoluted Mass Spectrum (processed data):
PEGylated oligo, raw electrospray data PEGylated oligo, deconvoluted data

Contact us for more information.