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MS Peptide & Protein Pricing

Standard pricing for peptide and protein mass spectral analysis

About Novatia’s peptide and protein analysis
All analyses use electrospray ionization (ESI)
Not sure if you need High Resolution or not? Click here
For questions about our MS analysis, email ms@enovatia.com.

Protein Analysis

AnalysisPrice Per AnalysisDescriptionExcel Sample Submission Sheet Code
LC/MS Profiling$275LCMS is used for all intact protein samples. Normal resolution is used to determine isotopic average masses in a sample. LCMS_P
LC/MS with sample treatment (see description for options)$325For the analysis of proteins in general. Sample treatment options include:
1) Deglycosylation by PNGase F
2) Disulfide reduction
3) PNGAse F and reduction
1. PNGase_LCMS
2. Reduction_LCMS
3. PNGAse_Reduction_LCMS
High Resolution (HRMS) LC/MS Exact Mass Profiling$350Exact (Monoisotopic) mass can be determined for proteins up to ~25 kD with < 3 ppm mass accuracy.HRMS_LCMS
Peptide Mapping LCMS$1500Detailed peptide mapping to confirm sequence and modifications of a target protein. See sample peptide mapping report.Peptide_Mapping

Peptide Analysis

AnalysisPrice Per AnalysisDescriptionExcel Sample Submission Sheet Code
Molecular Weight (MW) Confirmation$100Reasonably pure peptides only. Includes PNAs (peptide-nucleic acids). MW_Confirmation_Peptide
High Resolution Flow Injection$150Reasonably pure peptides only. Includes PNAs (peptide-nucleic acids).HRMS
LC/MS Profiling$275Nominal mass resolution is used to determine isotopic average masses in a sample. LCMS_P
High Resolution LC/MS Exact Mass Profiling$350Exact (Monoisotopic) mass can be determined for peptides up to ~25 kD with < 3 ppm mass accuracy.HRMS_LCMS
Peptide Mapping LCMS$1500Detailed peptide mapping to confirm sequence and modifications of a target protein. See sample peptide mapping report.Peptide_Mapping

mAb Analysis

AnalysisPrice Per AnalysisDescriptionExcel Sample Submission Sheet Code
LC/MS Profiling$275LCMS analysis is used to determine MAb average masses and reveals heterogeneity due to attached glycans or other modifications.LCMS_P
LC/MS with sample treatment (see comments for options)$325For the analysis of deglycosylated mAbs and/or mAb subunits. Sample treatment options include:
1) Deglycosylation by PNGase F
2) Disulfide reduction
3) Fab and Fc fragmentation
or any combination of the 3.
1. PNGase_LCMS
2.Reduction_LCMS
3. Fab_Fc_LCMS
Native LC/MS (see comments for options)$400Native LCMS conditions for the analysis of intact mAbs and/or mAb subunits. Most useful in the analysis of cysteine conjugated ligands.
Native_LCMS
Native LC/MS with sample treatment (see comments for options)$475Native LCMS conditions for the analysis of intact mAbs and/or mAb subunits. Most useful in the analysis of cysteine conjugated ligands.
Samples will be deglycosylated with PNGase F.
Native_PNGase_LCMS
Peptide Mapping LCMS$1500Detailed peptide mapping to confirm sequence and modifications of a target mAb. See sample peptide mapping report.Peptide_Mapping

Antibody Drug Conjugate Analysis

AnalysisPrice Per AnalysisDescriptionExcel Sample Submission Sheet Code
LC/MS Profiling and DAR calculation$325For the analysis of Intact ADCs.

Includes DAR (drug-to-antibody ratio) calculation.
It is recommended that a control sample be submitted along side DAR samples for a comparable analysis.
LCMS_DAR
LC/MS with sample treatment (see description for options) and DAR calculation$375For the analysis of deglycosylated ADCs and/or ADC subunits. Sample treatment options include:
1) Deglycosylation by PNGase F
2) Disulfide reduction
3) Fab and Fc fragmentation
or any combination of the 3.

Includes DAR (drug-to-antibody ratio) calculation.
It is recommended that a control sample be submitted along side DAR samples for a comparable analysis.
1. PNGase_LCMS_DAR
2.Reduction_LCMS_DAR
3. Fab_Fc_LCMS_DAR
Native LC/MS and DAR calculation$450Native LCMS conditions for the analysis of intact ADCs and/or ADC subunits. Most useful in the analysis of cysteine conjugated ligand samples.

Includes DAR (drug-to-antibody ratio) calculation.
It is recommended that a control sample be submitted along side DAR samples for a comparable analysis.
Native_LCMS_DAR
Native LC/MS with sample treatment (see description for options) and DAR calculation$500Native LCMS conditions for the analysis of intact ADCs and/or ADC subunits. Most useful in the analysis of cysteine conjugated ligand samples.
Samples will be deglycosylated with PNGase F.

Includes DAR (drug-to-antibody ratio) calculation.
It is recommended that a control sample be submitted along side DAR samples for a comparable analysis.
Native_PNGase_LCMS_DAR

Additional Services

ServicePrice
Applicable to:
Additional Data Interpretation & Reporting$400 / hrMS and NMR analysis
Sample Return$300 MS and NMR analysis
Variable Temperature$350 setup feeNMR Analysis only
Extended NMR Acquisition (1, 2, 4, 8 hours)$200/ hourNMR Analysis only
50-minute training session (see details below)$400MS and NMR analysis

50-minute training session: This service is meant to highlight the data provided in the report and how to view the posted MS or NMR data. This service is not meant to troubleshoot potential sample issues. Beneficial for first time submitters as we will explain the information provided in the data we have posted. If requesting this service, the results notification email sent by the analyst will provide times available to review the posted results. You will need to schedule a time that works best within the next 5 business days from the day the results email is sent.

Pricing and policies effective 09-Sept-2023.

ROUTINE ANALYSIS TERMS AND CONDITIONS:

  1. Typical turnaround time is 1-5 business days for most analyses. Rush service moves your submission to the front of the instrument queue for 2X charge. Nominal mass oligonucleotides and 1D NMR usually same day or next day. Large numbers of samples may take longer.
  2. Payment for services will be made by check, credit card, wire transfer or ACH.  An approved purchase order (Net 30) or credit card details will be provided to Novatia upon submitting an analysis request: http://www.enovatia.com/novatia-sample-submission-form/ When paying by credit card, transactions will process at the time service is provided. Invoices are due and payable within the time noted on the invoice, measured from the date of the invoice.
  3. Work is NOT performed under regulated conditions (e.g. cGxP) and is “for information only.”
  4. Customer represents that submitted samples do not warrant exceptional handling or precautions (e.g., as with radioactive samples, controlled substances, highly potent or cytotoxic compounds, etc.) and that any available safety information (safety data sheet, occupational exposure level, control banding, etc.) will be relayed to Novatia prior to sample shipment.
  5. After analysis, customer will receive an email to view results on Novatia’s Secure Web Portal: Most MS results are ProMass HTML or ACD PDF report;  NMR results include ACD PDF report and zip file of raw NMR data.
  6. If additional custom data interpretation/reporting is required (apart from what is explicitly included in Point 5), Novatia can provide a quote to the customer at our hourly rate of $400/hr.
  7. Novatia does not retain samples after analysis. If sample return is required this must be requested at the time of the submission using the sample submission Excel sheet.