MS Peptide & Protein Pricing
Standard pricing for peptide and protein mass spectral analysis
About Novatia’s peptide and protein analysis
All analyses use electrospray ionization (ESI)
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For questions about our MS analysis, email ms@enovatia.com.
Protein Analysis
| Analysis | Price Per Analysis | Description | Excel Sample Submission Sheet Code |
|---|---|---|---|
| LC/MS Profiling | $275 | LCMS is used for all intact protein samples. Normal resolution is used to determine isotopic average masses in a sample. | LCMS_P |
| LC/MS with sample treatment (see description for options) | $325 | For the analysis of proteins in general. Sample treatment options include: 1) Deglycosylation by PNGase F 2) Disulfide reduction 3) PNGAse F and reduction | 1. PNGase_LCMS 2. Reduction_LCMS 3. PNGAse_Reduction_LCMS |
| High Resolution (HRMS) LC/MS Exact Mass Profiling | $350 | Exact (Monoisotopic) mass can be determined for proteins up to ~25 kD with < 3 ppm mass accuracy. | HRMS_LCMS |
| Peptide Mapping LCMS | $1500 | Detailed peptide mapping to confirm sequence and modifications of a target protein. See sample peptide mapping report. | Peptide_Mapping |
Peptide Analysis
| Analysis | Price Per Analysis | Description | Excel Sample Submission Sheet Code |
|---|---|---|---|
| Molecular Weight (MW) Confirmation | $100 | Reasonably pure peptides only. Includes PNAs (peptide-nucleic acids). | MW_Confirmation_Peptide |
| High Resolution Flow Injection | $150 | Reasonably pure peptides only. Includes PNAs (peptide-nucleic acids). | HRMS |
| LC/MS Profiling | $275 | Nominal mass resolution is used to determine isotopic average masses in a sample. | LCMS_P |
| High Resolution LC/MS Exact Mass Profiling | $350 | Exact (Monoisotopic) mass can be determined for peptides up to ~25 kD with < 3 ppm mass accuracy. | HRMS_LCMS |
| Peptide Mapping LCMS | $1500 | Detailed peptide mapping to confirm sequence and modifications of a target protein. See sample peptide mapping report. | Peptide_Mapping |
mAb Analysis
| Analysis | Price Per Analysis | Description | Excel Sample Submission Sheet Code |
|---|---|---|---|
| LC/MS Profiling | $275 | LCMS analysis is used to determine MAb average masses and reveals heterogeneity due to attached glycans or other modifications. | LCMS_P |
| LC/MS with sample treatment (see comments for options) | $325 | For the analysis of deglycosylated mAbs and/or mAb subunits. Sample treatment options include: 1) Deglycosylation by PNGase F 2) Disulfide reduction 3) Fab and Fc fragmentation or any combination of the 3. | 1. PNGase_LCMS 2.Reduction_LCMS 3. Fab_Fc_LCMS |
| Native LC/MS (see comments for options) | $400 | Native LCMS conditions for the analysis of intact mAbs and/or mAb subunits. Most useful in the analysis of cysteine conjugated ligands. | Native_LCMS |
| Native LC/MS with sample treatment (see comments for options) | $475 | Native LCMS conditions for the analysis of intact mAbs and/or mAb subunits. Most useful in the analysis of cysteine conjugated ligands. Samples will be deglycosylated with PNGase F. | Native_PNGase_LCMS |
| Peptide Mapping LCMS | $1500 | Detailed peptide mapping to confirm sequence and modifications of a target mAb. See sample peptide mapping report. | Peptide_Mapping |
Antibody Drug Conjugate Analysis
| Analysis | Price Per Analysis | Description | Excel Sample Submission Sheet Code |
|---|---|---|---|
| LC/MS Profiling and DAR calculation | $325 | For the analysis of Intact ADCs. Includes DAR (drug-to-antibody ratio) calculation. It is recommended that a control sample be submitted along side DAR samples for a comparable analysis. | LCMS_DAR |
| LC/MS with sample treatment (see description for options) and DAR calculation | $375 | For the analysis of deglycosylated ADCs and/or ADC subunits. Sample treatment options include: 1) Deglycosylation by PNGase F 2) Disulfide reduction 3) Fab and Fc fragmentation or any combination of the 3. Includes DAR (drug-to-antibody ratio) calculation. It is recommended that a control sample be submitted along side DAR samples for a comparable analysis. | 1. PNGase_LCMS_DAR 2.Reduction_LCMS_DAR 3. Fab_Fc_LCMS_DAR |
| Native LC/MS and DAR calculation | $450 | Native LCMS conditions for the analysis of intact ADCs and/or ADC subunits. Most useful in the analysis of cysteine conjugated ligand samples. Includes DAR (drug-to-antibody ratio) calculation. It is recommended that a control sample be submitted along side DAR samples for a comparable analysis. | Native_LCMS_DAR |
| Native LC/MS with sample treatment (see description for options) and DAR calculation | $500 | Native LCMS conditions for the analysis of intact ADCs and/or ADC subunits. Most useful in the analysis of cysteine conjugated ligand samples. Samples will be deglycosylated with PNGase F. Includes DAR (drug-to-antibody ratio) calculation. It is recommended that a control sample be submitted along side DAR samples for a comparable analysis. | Native_PNGase_LCMS_DAR |
Additional Services
| Service | Price | Applicable to: |
|---|---|---|
| Additional Data Interpretation & Reporting | $400 / hr | MS and NMR analysis |
| Sample Return | $300 | MS and NMR analysis |
| Variable Temperature | $350 setup fee | NMR Analysis only |
| Extended NMR Acquisition (1, 2, 4, 8 hours) | $200/ hour | NMR Analysis only |
| 50-minute training session (see details below) | $400 | MS and NMR analysis |
50-minute training session: This service is meant to highlight the data provided in the report and how to view the posted MS or NMR data. This service is not meant to troubleshoot potential sample issues. Beneficial for first time submitters as we will explain the information provided in the data we have posted. If requesting this service, the results notification email sent by the analyst will provide times available to review the posted results. You will need to schedule a time that works best within the next 5 business days from the day the results email is sent.
Pricing and policies effective 09-Sept-2023.
ROUTINE ANALYSIS TERMS AND CONDITIONS:
- Typical turnaround time is 1-5 business days for most analyses. Rush service moves your submission to the front of the instrument queue for 2X charge. Peptide mapping usually within one week. Nominal mass oligonucleotides and 1D NMR usually same day or next day. Large numbers of samples may take longer.
- Payment for services will be made by check, credit card, wire transfer or ACH. An approved purchase order (Net 30) or credit card details will be provided to Novatia upon submitting an analysis request: http://www.enovatia.com/novatia-sample-submission-form/ When paying by credit card, transactions will process at the time service is provided. Invoices are due and payable within the time noted on the invoice, measured from the date of the invoice.
- Work is NOT performed under regulated conditions (e.g. cGxP) and is “for information only.”
- Customer represents that submitted samples do not warrant exceptional handling or precautions (e.g., as with radioactive samples, controlled substances, highly potent or cytotoxic compounds, etc.) and that any available safety information (safety data sheet, occupational exposure level, control banding, etc.) will be relayed to Novatia prior to sample shipment.
- After analysis, customer will receive an email to view results on Novatia’s Secure Web Portal: Most MS results are ProMass HTML or ACD PDF report; NMR results include ACD PDF report and zip file of raw NMR data.
- If additional custom data interpretation/reporting is required (apart from what is explicitly included in Point 5), Novatia can provide a quote to the customer at our hourly rate of $400/hr.