Are there any compatibility issues with ProMass on Windows 10?

The ProMass software is compatible with Windows 10.  However, please note that there is an extra process for getting the ProMass software to work on Windows 10 with the USB license key inside a virtual machine.  The Sentinel HASP/LDK run-time libraries need to be installed. ProMass for Xcalibur 4.0.2 and later, as well as ProMass for MassLynx 3.0 and later already installs the Sentinel libraries. If you are running an earlier version of ProMass, you can download the Sentinel run-time from here:

https://supportportal.gemalto.com/csm/?id=kb_article_view&sysparm_article=KB0018320

After clicking the link above, scroll to the bottom to accept the terms of the download.  Once you install the Sentinel Run-Time, the ProMass key should work properly.