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What’s New in ProMass for MassLynx 3.0?

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Updated graphics and branding, with more modern look and feel

Updated user interface gives ProMass a more modern look

New In-line Java-based spectrum viewer for interactively viewing spectra directly from ProMass reports

Clicking the [View Data] web link or double-clicking a spectrum within ProMass reports now activates a Java-based spectrum viewer.  Since the viewer is resident in the browser, it does not require an additional program to be installed to interactively view the spectra.  The viewer allows the user to highlight charge series contributing to a particular mass or determine the mass differences between peaks.  The spectra may be annotated and exported to high res. PNG files.

New automated drug-antibody ratio (DAR) calculation feature allows for robust, high-throughput ADC analysis (included with ProMass and ProMass HR)

For ADC analysis, ProMass can now calculate drug-antibody ratio (DAR) for intact protein analysis.  The user can activate DAR analysis by entering a few commands into the Target Info field of the sample list.  The identity of the modified proteins and number of attached drug molecules are shown in the Target Mass Summary table of the ProMass report.  The calculated DAR is shown as well. 
Clicking on the DAR value in the ProMass report shows a detailed calculation summary (in CSV format) of how the DAR was derived.
To activate DAR calculation, the user only needs to list the most abundant target masses of the unmodified protein and the drug mass with the DAR command in the Target Info field of the sample list.  For example, in row #1 above:
146820.5, 146982.7, 146658.4, DAR=516.45

New OligoSeq oligo sequence confirmation tool (ProMass HR only)

New OligoSeq tool is accessed from the ProMass Tools menu. 
The OligoSeq tool in ProMass HR is used to confirm oligonucleotide sequences using high resolution MS/MS or MSE data.  Given an input oligo sequence and a deisotoped MS fragmentation spectrum, OligoSeq can match the predicted zero-charged fragments against a deisotoped spectrum and produce an Excel sequence coverage report and chart as shown below.
The example shows the detailed Excel report generated by OligoSeq.  The report shows the calculated a-B, a, b, c, d, w, x, y, and z ions for the input oligo sequence.  The experimentally observed ions (exp), error in ppm (err), and intensities (int) are also shown for each series of ions.  
The sequence confirmation chart is a stack plot showing the summed intensities of fragments originating from either the 3′ or the 5′ end. 
  • New mass peak detection algorithm for ZNova deconvolutions more accurately labels peaks and rejects unresolved shoulders and noise peaks. Optional centroid output feature now reports the peak area of each deconvoluted mass instead of intensity for more accurate relative quantitation of ProMass results.
  • In ProMass HR, it is now possible to deisotope and report monoisotopic OR average mass
  • ProMass reports can now be saved as PDF
  • Updated ProMass On-line Help to better support HR and other new features, including PDF User Guide
  • Data station enhancements:
    • ProMass now supports MS Office 365
    • Windows Remote Desktop processing is now supported with one concurrent user

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